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Toby Keith’s Gastric Cancer

Toby Keith's Gastric Cancer

Toby Keith, a country star, is a true powerhouse. Toby Keith, 60, has more than 40 hits in the top 10, and 30 songs that reached No. The song reached No. 1 on the charts. Keith took to Twitter this week to share with his fans a secret health condition that he has been keeping private for 6 months.

“Last fall, I was diagnose with stomach cancer. The last six months have been spent receiving chemotherapy, radiation, and surgery. So far, so good. I need to take some time to relax, breathe, and recover.”

Keith was touring for his new album Peso In My Pocket. At the time of the announcement, his website had been taken down.

Keith has been a long-standing supporter of pediatric patients with cancer. After the passing of his friend’s child to cancer, he founded an Oklahoma non-profit called Ally’s House. He founded the Toby Keith Foundation in 2006, and it runs the OK Kids Corral, which provides housing and support for children with cancer and their families.

Toby Keith also performed for over 250,000 military personnel in 17 countries, including shows in Iraq, Afghanistan, and other parts of the USO.

Gastric Cancer

According to the World Health Organization gastric cancer is the sixth-most common type of cancer, and third-leading cause of death from cancer. It is expected that in the United States there will be 26380 new cases and 11090 deaths due to gastric cancer by 2022. About 0.8% of people are at risk for developing stomach cancer in their lifetime.

The stomach is a part of the digestive system, but it is distinct from cancers in the colon, colon, or intestines. There are five main parts to the stomach. The proximal part of the stomach is the cardia, fundus and body. This is the closest to the esophagus. The distal stomach is made up of the antrum where food and gastric juice mix, as well as the pylorus which acts like a valve to regulate the stomach’s emptying into the small intestine.

The stomach wall is composed of three layers: the mucosal layer (innermost), the muscularis layer (middle), and the serosal layer (outermost). The cells that line the mucosal layer of the stomach cause gastric cancer. As it grows, it spreads to the outer layers.

There are many types of stomach cancers.

  • Adenocarcinomas account for 90% to 95% of all gastric cancers. The cells that make up the mucosa are responsible for this type of cancer.
  • About 4% of stomach cancers are caused by gastric lymphomas. These cancers of lymph are mostly mucosa-associated lymphoid tissues gastric lymphoma and diffuse large B-cell lymphoma.
  • Gastrointestinal stromal Tumors (GIST), a rare form of cancer, appear to originate in cells in the wall cells of the GI tract. These cells are called interstitial cells of Cajal. GIST can occur anywhere in the digestive system, but most commonly in the stomach (60%) and small intestine (25%).
  • Carcinoid tumors can be tumors that originate in hormone-producing stomach cells. These tumors rarely spread to other organs. Carcinoid tumors account for about 3% of stomach cancers.

There are two types of gastric cancer: diffuse and intestinal. The intestinal variety is well-differentiated. Cells tend to form into tubular and glandular structures. This gives rise to the terms tubular, papillary or mucinous. Rarely, adenosquamous cancers can occur.

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Diffuse adenocarcinomas can be undifferentiated, poorly differentiated, and lack gland formation. This type of adenocarcinoma may infiltrate the stomach wall (i.e. linitis plasta).

There are some tumors that have both diffuse and intestinal features.

What are some risk factors for gastric carcinoma?

The following are recognize risk factors to gastric cancer:

  • Helicobacter Pylori Gastric Infection
  • Ageing in advanced
  • Male gender
  • Low intake of fruits and vegetables
  • Consume a lot of salted, smoked or preserved foods
  • Chronic atrophic gastritis
  • Intestinal metaplasia is a condition where the stomach lining and cells that line the intestines are replaced by abnormal ones.
  • Pernicious anemia
  • Gastric adenomatous Polyps
  • Gastric cancer in the family
  • Cigarette smoking
  • Menetrier disease (giant hypertrophic stomachitis)
  • Epstein-Barr virus infection
  • Familial syndromes, including familial adenomatous polyposis

What are the signs and symptoms of gastric cancer?

Gastric cancer symptoms can often be caused by common conditions and they are often ignored. Most patients present with advanced stage disease, so the majority have these symptoms.

These symptoms can occur in the early stages of gastric cancer.

  • Indigestion and stomach discomfort
  • After eating, you feel bloated.
  • Mild nausea
  • Appetite loss
  • Heartburn

The following symptoms and signs may be present in advanced stages of gastric carcinoma.

  • There is blood in the stool
  • Vomiting
  • No known cause for weight loss
  • Stomach pain
  • Jaundice
  • Ascites
  • Trouble swallowing

Survival Prognosis

The National Cancer Institute has the following:

The prognosis for patients with gastric cancer depends on the extent of the tumor. This includes nodal involvement as well as direct tumor extension beyond gastric walls. Some prognostic information may also be provided by tumor grade.

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“About 50% of patients with localize distal stomach cancer can be treate. Only 10% to 20% of cases in the United States are diagnosed with early-stage disease. Rest of the patients have metastatic disease at distant or regional sites. These patients have a 5 year survival rate of almost zero for patients with disseminated cancer and almost 50% for patients with localized distal stomach cancers that are confined to resectable region disease. Patients with proximal stomach cancer have a 5-year survival rate between 10% and 15%, even if they have an apparent localized condition. Patients with disseminate stomach cancer can be treated to alleviate symptoms and prolong survival. However, it is rare for patients to experience long-term remissions. His gastric cancer survival rate is very low.

Treatment of Gastric Cancer

Surgery with regional lymphadenectomy for early-stage disease is the best option. For patients with advanced disease, resection may be combine with chemotherapy, radiation therapy or targeted therapy with monoclonal antibodies or multikinase inhibits, or any combination thereof.

The FDA has approved the following drugs for treating gastric cancer:

  • Ramucirumab (Cyramza)
  • Docetaxel
  • Doxorubicin Hydrochloride
  • Fam-trastuzumab deruxtecan-nxki (Enhertu)
  • Fluorouracil
  • Trastuzumab (Herceptin)
  • Pembrolizumab (Keytruda)
  • Tipiracil hydrochloride and trifluridine ( Leonsurf).
  • Mitomycin, (Jelmyto).
  • Nivolumab (Opdivo)

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